YAO Fei, ZENG Jian-ying, CHEN Ji-bing et al.
[Abstract]
Objective To compare a dual-freeze protocol with atriple-freeze protocol for pulmonary cryoabiation in aporcine lung model.
Method Cryoablation with a dual-freeze(10-5-10-5,min) protocol and triple-freeze( 5-5-5-5-10-5, min) protocol in normal lung of 5
Tibet pigs were performed under exposed operation. Temperature changes of cryoprobes and diameter changes of iceballs were measured during the ablation, and then pathological changes of cryozones in lungs were reviewed 7 days after cryosurgery, and the surface and depth cryolesions were measured.
Result After two or three freeze-thaw cycles, different diameters on iceball surface were formed, and seven days after cryosurgery, there were simiiar surface and depth cryolesions in dual-freeze protocoland triple-freeze protocol. Pathoiogicaiiy, the triple freezing protocol was associated with longer complete necrosis zone than the dual freezing protocol.
Conclusion Therefore, with the same freezing time, the triple-freeze protocol may become a more powerful lung-ablation method in cryosurgical application.
[key words] Puimonary cryoabiation; Freeze protocols; Tibet pig model
不同循环冷冻消融术对西藏小型猪肺部冷冻消融效果的比较.pdf