TAKE CARCINOEMBRYONIC ANTIGEN AS PROGNOSTIC FACTORS FOR IV STAGE NON-SMALL CELL LUNG CANCER BY PERCUTANEOUS CRYOSURGERY
LI Haibo，MU Feng，TANG Kui，et al
【Abstract】
0bjective Determined whether cryoablation—induced changes in serum CEA levels correlated with tumor type(adenocarcinoma or squamous carcinoma)and treatment type(comprehensive therapy or palliative therapy)in patients with metastatic NSCLC，and assessed whether pre—treatment CEA levels predicted overall survival (OS)time．
Methods We retrospectively reviewed the clinical data of 79 patients with metastatic NSCLC who underwent comprehensive(58 patients)or palliative(21 patients)therapy．Pre- and post-cryoablation serum CEA levels and overall survival time were determined for all patients．
Results Cryoablation significantly reduced CEA levels in adenocarcinoma，but not squamous carcinoma，patients．Among adenocarcinoma patients，the cryoablation—induced reduction in CEA levels Was significantly greater after comprehensive treatment than after palliative treatment；the OS of patients under comprehensive cryoablation Was longer than those under palliative treatment．Among adenocarcinoma patients receiving comprehensive cryoablation．0S was significantly longer in those with normal pre-treatment serum CEA levels than in those with abnormal pre-treatment serom CEA levels．
Conclusion Pretreatment level and change of serom CEA can be a good indicator for therapeutic effects and OS in metastatic NSCLC patients under percutaneous cryosurgery．
【Key words】Cryosurgery，Carcinoembryonic antigen，Metastatic non-small cell lung cancer，Prognosis
癌胚抗原(CEA)在Ⅳ期非小细胞肺癌经皮冷冻治疗中的疗效评估及预后作用.pdf